NON-RESPONSIVENESS TO ORAL ANTIPLATELET TREATMENT

Non-responsiveness to oral antiplatelet treatment

Background: Antiplatelet treatment with aspirin and/or clopidogrel reduces the incidence of atherothrombotic events but does not abolish them altogether.In a multifactorial pathological process such as atherothrombosis no single preventive strategy can be completely successful, yet prescribing antiplatelet treatment without routinely measuring its

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High performance liquid chromatography preparation of the molecular species of GM1 and GD1a gangliosides with homogeneous long chain base composition.

A semi-preparative, analytical high performance liquid chromatographic (HPLC) procedure is described for the isolation of molecular species of GM1 and GD1a gangliosides containing a single long chain base, C18 or C20 sphingosine, C18 or C20 sphinganine, each in its natural erythro or unnatural threo form.The threo forms were obtained from 2,3-dichl

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